Assessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy.

ABSTRACT:

Objective

We aimed to evaluate the limit of detection of high-sensitivity troponin (hs-cTn) and Thrombolysis In Myocardial Infarction (TIMI) score combination rule-out strategy suggested within the 2016 National Institute for Health and Care Excellence (NICE) Chest Pain of Recent Onset guidelines and establish the optimal TIMI score threshold for clinical use.

Methods

A pooled analysis of adult patients presenting to the emergency department with chest pain and a non-ischaemic ECG, recruited into six prospective studies, from Australia, New Zealand and the UK. We evaluated the sensitivity of TIMI score thresholds from 0 to 2 alongside hs-cTnT or hs-cTnI for the primary outcome of major adverse cardiac events within 30 days.

Results

Data were available for 3159 patient

SUBMITTER: Carlton EW 

PROVIDER: S-EPMC5890641 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature