Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort.

ABSTRACT:

Objectives

To describe the characteristics of children and adults with incident type 1 diabetes in contemporary, multiethnic UK, focusing on differences between the islet autoantibody negative and positive.

Design

Observational cohort study.

Setting

146 mainly secondary care centres across England and Wales.

Participants

3312 people aged ≥5 years were recruited within 6 months of a clinical diagnosis of type 1 diabetes via the National Institute for Health Research Clinical Research Network. 3021 were of white European ethnicity and 291 (9%) were non-white. There was a small male predominance (57%). Young people <17 years comprised 59%.

Main outcome measures

Autoantibody status and characteristics at presentation.

Results

The majority presented wi

SUBMITTER: Bravis V 

PROVIDER: S-EPMC5893930 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature