Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behcet's disease.

ABSTRACT:

Objective

Behçet's disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variable number tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population.

Methods

One hundred nine patients (60 females, 49 males; the mean age±standard deviation [SD] was 36.56±9.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the mean age±SD was 36.64±2.294 years) were examined in the study. For genotyping, polymerase chain reaction-restriction fragment length polymorphism analysis was employed. Data were analyzed us

SUBMITTER: Dursun G 

PROVIDER: S-EPMC5895147 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature