Genetic variants of SLC12A3 modulate serum lipid profiles in a group of Mongolian pedigree population.

ABSTRACT:

Background

The serum lipid profile, including LDL-C level, is associated with hypertension which is the major cause of cerebrovascular disease (CVD) amounting 30% of global death rate. Previous work also demonstrated important roles of genetic variants of SLC12A3 gene on human CVD, hypertension and other diseases in Mongolian population. However, the relationship between SLC12A3 gene polymorphisms on individuals' lipid profile is still unknown.

Methods

A panel of 15 SNPs of SLC12A3 gene was genotyped within a 424 Mongolians pedigree cohort. The associations between SLC12A3 polymorphisms and four lipid profiles were analyzed by family-based association test (FBAT) and confirmed with haplotype analysis.

Results

From both single site and haplotype analyses, the results d

SUBMITTER: An C 

PROVIDER: S-EPMC5902855 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature