B-cell populations are expanded in breast cancer patients compared with healthy controls.

ABSTRACT:

Background

Historically, humoral immunity was considered unimportant in anti-tumor immunity, and the differentiation and anti-tumor activity of B cells in breast cancer are poorly understood. However, it was recently discovered that B cells participate in tumor immunity through both antibody production and immunosuppressive mechanisms. We analyzed the expression of B-cell differentiation markers in detail using fluorescence-activated cell sorting to investigate the relationship between B-cell subsets and breast cancer etiology.

Methods

Blood samples were taken from breast cancer patients and healthy donors, and peripheral blood mononuclear cells were collected. B cells at various stages of differentiation were identified by the expression of combinations of the cell surface

SUBMITTER: Tsuda B 

PROVIDER: S-EPMC5906508 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature