The influence of alendronate and tooth extraction on the incidence of osteonecrosis of the jaw among osteoporotic subjects.

ABSTRACT:

Background

Although bisphosphonate-related osteonecrosis of the jaw (ONJ) develops mainly after tooth extractions (TEs), the strength of the association between them and how the existence of the disease among bisphosphonate (BP)-treated osteoporotic patients exposed to TE remain uncertain.

Methods

A nationwide retrospective cohort study investigated the influence of alendronate and TE on the development of ONJ.

Results

Incidence of ONJ following long-term alendronate therapy was 262/100,000 person-years, while no event developed in the control group on raloxifene. Overall prevalence of ONJ in osteoporotic subjects receiving alendronate was estimated at 0.34% which rose to 2.16% after TE. Multiple logistic regression analysis, adjusted for the potential confounders, sh

SUBMITTER: Chiu WY 

PROVIDER: S-EPMC5918995 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature