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Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547.

ABSTRACT: Chemical investigation of the marine algal-derived endophytic fungus Aspergillus alabamensis EN-547 resulted in the isolation of 4-epi-seco-shornephine A methyl ester (1) and 4-epi-seco-shornephine A carboxylic acid (2), two new secondary metabolites having a rare diketomorpholine motif, and 28-acetoxy-12?,15?,25-trihydroxyergosta-4,6,8(14),22-tetraen-3-one (3), a new highly conjugated ergostane-type steroid, together with four known metabolites (4-7). Their chemical structures were elucidated by detailed analysis of their NMR spectra, ECDs, HRESIMS, optical rotation, and X-ray crystallographic data, and by comparison with literature data as well. The antimicrobial activities of compounds 1-7 were evaluated.

SUBMITTER: Yang SQ 

PROVIDER: S-EPMC5923401 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547.

Yang Sui-Qun SQ   Li Xiao-Ming XM   Li Xin X   Chi Lu-Ping LP   Wang Bin-Gui BG  

Marine drugs 20180331 4

Chemical investigation of the marine algal-derived endophytic fungus <i>Aspergillus alabamensis</i> EN-547 resulted in the isolation of 4-<i>epi</i>-<i>seco</i>-shornephine A methyl ester (<b>1</b>) and 4-<i>epi</i>-<i>seco</i>-shornephine A carboxylic acid (<b>2</b>), two new secondary metabolites having a rare diketomorpholine motif, and 28-acetoxy-12<i>β</i>,15<i>α</i>,25-trihydroxyergosta-4,6,8(14),22-tetraen-3-one (<b>3</b>), a new highly conjugated ergostane-type steroid, together with fou  ...[more]

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