A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers.

ABSTRACT:

Purpose

Benzoate and phenylbutyrate are widely used in the treatment of urea cycle disorders, but detailed studies on pharmacokinetics and comparative efficacy on nitrogen excretion are lacking.

Methods

We conducted a randomized, three-arm, crossover trial in healthy volunteers to study pharmacokinetics and comparative efficacy of phenylbutyrate (NaPB; 7.15 g•m^-2BSA•day^-1), benzoate (NaBz; 5.5 g•m^-2BSA•day^-1), and a combination of two medications (MIX arm; 3.575 g NaPB and 2.75 g NaBz•m^-2BSA•day^-1) on nitrogen excretion. Stable isotopes were used to study effects on urea production and dietary nitrogen disposal.

Results

The conjugation efficacy for both phenylbutyrate and benzoate was 65%; conjugation w

SUBMITTER: Nagamani SCS 

PROVIDER: S-EPMC5924481 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature