Ontology highlight
ABSTRACT:
SUBMITTER: Vizcardo R
PROVIDER: S-EPMC5930030 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cell reports 20180301 12
Induced pluripotent stem cell (iPSC)-derived T cells may provide future therapies for cancer patients, but those generated by current methods, such as the OP9/DLL1 system, have shown abnormalities that pose major barriers for clinical translation. Our data indicate that these iPSC-derived CD8 single-positive T cells are more like CD4<sup>+</sup>CD8<sup>+</sup> double-positive T cells than mature naive T cells because they display phenotypic markers of developmental arrest and an innate-like phen ...[more]