The Impact of Dopamine on Insulin Secretion in Healthy Controls.

ABSTRACT:

Objective

Dopamine is very commonly used in the critical care setting and impacts glucose homeostasis. In some studies, it is noted to increase insulin resistance or decrease insulin secretion. The role of insulin secretion in response to dopamine is incompletely understood.

Methods

Eight individuals underwent a hyperglycemic clamp with a dopamine infusion, and eight controls underwent hyperglycemic clamp alone. Insulin, C-peptide, glucagon, cortisol, and norepinephrine (NE) concentrations were measured at various time points. An index of insulin sensitivity (M/I) was calculated. Statistical comparison between the control and treatment arm was done using repeated measures ANOVA. The data is expressed as mean ± standard deviation. Paired t-test was used to compare pre-

SUBMITTER: Underland LJ 

PROVIDER: S-EPMC5930523 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature