Pathogenic T_H17 inflammation is sustained in the lungs by conventional dendritic cells and Toll-like receptor 4 signaling.

ABSTRACT:

Background

Mechanisms that elicit mucosal T_H17 cell responses have been described, yet how these cells are sustained in chronically inflamed tissues remains unclear.

Objective

We sought to understand whether maintenance of lung T_H17 inflammation requires environmental agents in addition to antigen and to identify the lung antigen-presenting cell (APC) types that sustain the self-renewal of T_H17 cells.

Methods

Animals were exposed repeatedly to aspiration of ovalbumin alone or together with environmental adjuvants, including common house dust extract (HDE), to test their role in maintaining lung inflammation. Alternatively, antigen-specific effector/memory T_H17 cells, generated in culture with CD4⁺ T cells from Il1

SUBMITTER: Shalaby KH 

PROVIDER: S-EPMC5951733 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature