Cell based therapy enhances activation of ventral premotor cortex to improve recovery following primary motor cortex injury.

ABSTRACT: Stroke results in enduring damage to the brain which is accompanied by innate neurorestorative processes, such as reorganization of surviving circuits. Nevertheless, patients are often left with permanent residual impairments. Cell based therapy is an emerging therapeutic that may function to enhance the innate neurorestorative capacity of the brain. We previously evaluated human umbilical tissue-derived cells (hUTC) in our non-human primate model of cortical injury limited to the hand area of primary motor cortex. Injection of hUTC 24 h after injury resulted in significantly enhanced recovery of fine motor function compared to vehicle treated controls (Moore et al., 2013). These monkeys also received an injection of Bromodeoxyuridine (BrdU) 8 days after cortical injury to label cells unde

SUBMITTER: Orczykowski ME 

PROVIDER: S-EPMC5955823 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature