The Utility of Urinalysis in Determining the Risk of Renal Relapse in ANCA-Associated Vasculitis.

ABSTRACT:

Background and objectives

The significance of persistent hematuria or proteinuria in patients with ANCA-associated vasculitis who are otherwise in clinical remission is unclear.

Design, setting, participants, & measurements

A post hoc analysis was conducted using participants enrolled in two randomized, placebo-controlled clinical trials who had active GN due to ANCA-associated vasculitis, had positive ANCA, and achieved remission by month 6. Dipstick and microscopic urinalyses were performed at each visit. Persistent hematuria or proteinuria for at least 6 months and the cumulative duration of hematuria were examined. Renal relapse was defined as new or worsening red blood cell casts and/or worsening kidney function according to the Birmingham Vasculitis Activity Sco

SUBMITTER: Rhee RL 

PROVIDER: S-EPMC5967421 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature