Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line.

ABSTRACT: Fibrillation is the most common arrhythmia observed in clinical practice. Understanding of the mechanisms underlying its initiation and maintenance remains incomplete. Functional re-entries are potential drivers of the arrhythmia. Two main concepts are still debated, the "leading circle" and the "spiral wave or rotor" theories. The homogeneous subclone of the HL1 atrial-derived cardiomyocyte cell line, HL1-6, spontaneously exhibits re-entry on a microscopic scale due to its slow conduction velocity and the presence of triggers, making it possible to examine re-entry at the cellular level. We therefore investigated the re-entry cores in cell monolayers through the use of fluorescence optical mapping at high spatiotemporal resolution in order to obtain insights into the mechanisms of re-entr

SUBMITTER: Houston C 

PROVIDER: S-EPMC6004038 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature