Dataset Information

Association of leisure-time physical activity with total and cause-specific mortality: a pooled analysis of nearly a half million adults in the Asia Cohort Consortium.

ABSTRACT:

Background

Most previous studies evaluating the association between leisure-time physical activity (LTPA) and risk of death were conducted among generally healthy individuals of European ancestry. We investigated the association of LTPA with all-cause and cause-specific mortality among East Asian populations, including healthy individuals and those with existing chronic diseases, which has been less well characterized.

Methods

We performed pooled analyses among 467 729 East Asian individuals recruited in nine prospective cohorts included in the Asia Cohort Consortium. Cox proportional hazards regressions were used to derive hazard ratios (HRs) and 95% confidence intervals (CIs) associated with LTPA after adjusting for age, sex, education and marital and smoking status.

Results

During a mean follow-up period of 13.6 years, 65 858 deaths were identified. Compared with those who reported no or less than 1 h of LTPA per week, an inverse association was observed between the amount of LTPA and all-cause and cause-specific mortality (P for trend < 0.001). The strength of the inverse association was stronger for death due to cardiovascular diseases and causes other than cancer deaths. An inverse association of LTPA with total mortality was observed among individuals with a severe and often life-threatening disease: cancer, stroke or coronary heart disease [hazard ratio (HR) = 0.81, 95% CI = 0.73-0.89 for high vs low LTPA) and those with other chronic diseases such as diabetes or hypertension (HR = 0.86, 95% CI = 0.80-0.93 for high vs low LTPA). No clear modifying effects by sex, body mass index or smoking status were identified.

Conclusions

Regular participation in LTPA is associated with reduced mortality in middle-aged and elder Asians regardless pre-existing health conditions.

SUBMITTER: Liu Y

PROVIDER: S-EPMC6005114 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Publications

Association of leisure-time physical activity with total and cause-specific mortality: a pooled analysis of nearly a half million adults in the Asia Cohort Consortium.

Liu Ying Y Shu Xiao-Ou XO Wen Wanqing W Saito Eiko E Rahman M Shafiur MS Tsugane Shoichiro S Tamakoshi Akiko A Xiang Yong-Bing YB Yuan Jian-Min JM Gao Yu-Tang YT Tsuji Ichiro I Kanemura Seiki S Nagata Chisato C Shin Myung-Hee MH Pan Wen-Harn WH Koh Woon-Puay WP Sawada Norie N Cai Hui H Li Hong-Lan HL Tomata Yasutake Y Sugawara Yumi Y Wada Keiko K Ahn Yoon-Ok YO Yoo Keun-Young KY Ashan Habibul H Chia Kee Seng KS Boffetta Paolo P Inoue Manami M Kang Daehee D Potter John D JD Zheng Wei W

International journal of epidemiology 20180601 3

<h4>Background</h4>Most previous studies evaluating the association between leisure-time physical activity (LTPA) and risk of death were conducted among generally healthy individuals of European ancestry. We investigated the association of LTPA with all-cause and cause-specific mortality among East Asian populations, including healthy individuals and those with existing chronic diseases, which has been less well characterized.<h4>Methods</h4>We performed pooled analyses among 467 729 East Asian ...[more]

PMID: 29490039

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Dataset Information

Association of leisure-time physical activity with total and cause-specific mortality: a pooled analysis of nearly a half million adults in the Asia Cohort Consortium.

Background

Methods

Results

Conclusions

Publications

Association of leisure-time physical activity with total and cause-specific mortality: a pooled analysis of nearly a half million adults in the Asia Cohort Consortium.

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