Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.

ABSTRACT:

Rationale

Albuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide. There are significant racial/ethnic differences in albuterol drug response.

Objectives

To identify genetic variants important for bronchodilator drug response (BDR) in racially diverse children.

Methods

We performed the first whole-genome sequencing pharmacogenetics study from 1,441 children with asthma from the tails of the BDR distribution to identify genetic association with BDR.

Measurements and main results

We identified population-specific and shared genetic variants associated with BDR, including genome-wide significant (P < 3.53 × 10^-7) and suggestive (P < 7.06 × 10^-6) loci near genes previously associated with lung capacity (DNAH5), i

SUBMITTER: Mak ACY 

PROVIDER: S-EPMC6006403 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature