Inhibition of the substantia nigra pars reticulata produces divergent effects on sensorimotor gating in rats and monkeys.

ABSTRACT: The basal ganglia are an evolutionarily old group of structures, with gross organization conserved across species. Despite this conservation, there is evidence suggesting that anatomical organization of a key output nucleus of the basal ganglia, the substantia nigra pars reticulata (SNpr), diverges across species. Nevertheless, there are relatively few comparative studies examining the impact of manipulations of SNpr across species. Here, we evaluated the role of SNpr in a highly conserved behavior: prepulse inhibition of the acoustic startle response (PPI). We performed parallel experiments in both rats and rhesus macaques using intracranial microinfusions of GABA_A agonist muscimol to investigate the role of SNpr in PPI. SNpr inactivation significantly disrupted PPI in rats, co

SUBMITTER: Aguilar BL 

PROVIDER: S-EPMC6008324 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature