Ontology highlight
ABSTRACT:
SUBMITTER: Wicker E
PROVIDER: S-EPMC6936676 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20191216 52
Three decades of studies have shown that inhibition of the <i>substantia nigra pars reticulata</i> (SNpr) attenuates seizures, yet the circuits mediating this effect remain obscure. SNpr projects to the deep and intermediate layers of the superior colliculus (DLSC) and the pedunculopontine nucleus (PPN), but the contributions of these projections are unknown. To address this gap, we optogenetically silenced cell bodies within SNpr, nigrotectal terminals within DLSC, and nigrotegmental terminals ...[more]