Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

ABSTRACT:

Background

Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer.

Method

Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis to generate a signature. The signature was independently validated in eleven prostate cancer cohorts and a bladder cancer phase III randomized trial of radiotherapy alone or with carbogen and nicotinamide (CON).

Results

A 28-gene signature was derived. Patients with high signature scores had poorer biochemical recurrence free survivals in six of eight independent cohorts of prostatectomy-treated patients (Log rank test P < .05), with borderline significances achieved in the ot

SUBMITTER: Yang L 

PROVIDER: S-EPMC6014579 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature