Comparative analysis of binding patterns of MADS-domain proteins in Arabidopsis thaliana.

ABSTRACT:

Background

Correct flower formation requires highly specific temporal and spatial regulation of gene expression. In Arabidopsis thaliana the majority of the master regulators that determine flower organ identity belong to the MADS-domain transcription factor family. The canonical DNA binding motif for this transcription factor family is the CArG-box, which has the consensus CC(A/T)₆GG. However, so far, a comprehensive analysis of MADS-domain binding patterns has not yet been performed.

Results

Eight publicly available ChIP-seq datasets of MADS-domain proteins that regulate the floral transition and flower formation were analyzed. Surprisingly, the preferred DNA binding motif of each protein was a CArG-box with an NAA extension. Furthermore, motifs of other transcr

SUBMITTER: Aerts N 

PROVIDER: S-EPMC6019531 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature