Functional Polymorphism in the MSI1 Gene Promoter Confers a Decreased Risk of Lung Cancer in Chinese by Reducing MSI1 Expression.

ABSTRACT:

Background

Musashi1 (MSI1) is a characteristic stem cell marker that regulates the balance between cell self-renewal and differentiation. Evidence has identified MSI1 as a pivotal oncogenic regulator in diverse malignancies. However, little evidence uncovers the role of genetic variations of MSI1 gene in cancer etiology.

Objective

The aim of this study was to investigate the association between genetic variants in the MSI1 gene and lung cancer risk.

Methods

Based on a two-stage retrospective study with a total of 1559 patients with lung cancer and 1667 healthy controls, we evaluated the relevance between three putative functional SNPs in the MSI1 promoter (i.e., -2696T>C[rs7959801], -2297T>C[rs3742038] and -1081C>T[rs34570155]) and lung cancer risk.

Results

We

SUBMITTER: Liu L 

PROVIDER: S-EPMC6030856 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature