Δ³,2-Hydroxybakuchiol Attenuates Depression in Multiple Rodent Models Possibly by Inhibition of Monoamine Transporters in Brain.

ABSTRACT: Δ³,2-Hydroxybakuchiol is isolated from Psoralea corylifolia (L.), which has therapeutic applications in traditional Chinese medicine. Our previous studies have showed that Δ³,2-hydroxybakuchiol inhibited the decreased activity of reserpinized mice, suggestive of its antidepressive potential. In this study, we explored the antidepressant profile of Δ³,2-hydroxybakuchiol in various rodent models and its possible monoamine-modulating mechanism. Δ³,2-Hydroxybakuchiol significantly reduced immobility time of mice in forced swim test and tail suspension test. Δ³,2-Hydroxybakuchiol also significantly increased sucrose consumption in chronic unpredictable mild stress (CUMS) rat model. Furthermore, isotope uptake study showed that Δ

SUBMITTER: Zhao G 

PROVIDER: S-EPMC6031082 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature