Matrix Metalloproteinase-1 Gene Polymorphism Associated with Ultrasound-Assessed Carotid Thickness among Older Adults.

ABSTRACT:

Background and aim

Due to the high incidence of vascular diseases, it is necessary to identify new circulating or structural markers for predicting risk for chronic diseases. Some studies suggest that MMP1 gene polymorphisms are associated with the enzyme expression levels in situ (e.g., in atherosclerotic plaques).

Objectives

Thus, the study of this polymorphism may help understanding the pathophysiology of coronary disease.

Methods

We performed cross-sectional clinical and laboratory evaluations (including measurement of intima-media thickness of carotid arteries) and genotyping of the MMP1 SNP rs495366 (A/G) in 366 elderly people.

Results

No significant differences between genotypes were noted for biochemical, metabolic, inflammatory, or clinical variables e

SUBMITTER: Morais Junior GS 

PROVIDER: S-EPMC6033251 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature