Association between RAD51 135 G/C polymorphism and risk of 3 common gynecological cancers: A meta-analysis.

ABSTRACT:

Aim

Available data concerning the association between RAD51 135G/C (rs1801320) polymorphism and the risk of 3 common gynecological cancers still could not reach a consensus. Thus, we conducted a meta-analysis to explore the relationship.

Methods

Several electronic databases and bibliographies of relevant articles were screened to identify the studies up to July 2017. Then a meta-analysis was performed to evaluate the connection between 3 common gynecological tumors' susceptibility and RAD51 135G/C polymorphism in different inheritance models. Simultaneously, we did subgroup analysis and sensitivity analysis if necessary.

Results

A total of 11 articles including 14 studies involving 4097 cases and 5890 controls were included in this meta-analysis. Overall, RAD51 135G/C

SUBMITTER: Zeng X 

PROVIDER: S-EPMC6039596 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature