Dataset Information

Nut consumption and the risk of oesophageal squamous cell carcinoma in the Golestan Cohort Study.

ABSTRACT:

Background

Nut consumption has been inversely associated with gastric cancer incidence in US-based studies, but not with oesophageal cancer. However, there is aetiologic heterogeneity, among oesophageal squamous cell carcinoma (ESCC) cases in low-risk vs. high-risk populations. The objective of this study was to evaluate the association between nut consumption and risk of ESCC in a high-risk population.

Methods

The Golestan Cohort Study enroled 50,045 participants in Northeastern Iran, between 2004 and 2008. Intake of peanuts, walnuts and mixed nuts (including seeds) were assessed using a validated food frequency questionnaire at baseline. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals for subsequent ESCC adjusted for potential confounders. Non-consumers of nuts were used as the reference category and the consumers were categorised into tertiles.

Results

We accrued 280 incident ESCC cases during 337,983 person-years of follow up. Individuals in the highest tertiles of total nut consumption, and mixed nut consumption were significantly associated with lower risk of developing ESCC compared to non-consumers (HR = 0.60, 95% CI = 0.39-0.93, p-trend = 0.02, and HR = 0.52, 95% CI = 0.32-0.84, p trend = 0.002, respectively).

Conclusions

We found a statistically significant inverse association between total nut consumption and the risk of ESCC in this high-risk population.

SUBMITTER: Hashemian M

PROVIDER: S-EPMC6048068 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Publications

Nut consumption and the risk of oesophageal squamous cell carcinoma in the Golestan Cohort Study.

Hashemian Maryam M Murphy Gwen G Etemadi Arash A Poustchi Hossein H Sharafkhah Maryam M Kamangar Farin F Pourshams Akram A Malekshah Akbar Fazeltabar AF Khoshnia Masoud M Gharavi Abdolsamad A Hekmatdoost Azita A Brennan Paul J PJ Boffetta Paolo P Dawsey Sanford M SM Abnet Christian C CC Malekzadeh Reza R

British journal of cancer 20180628 2

<h4>Background</h4>Nut consumption has been inversely associated with gastric cancer incidence in US-based studies, but not with oesophageal cancer. However, there is aetiologic heterogeneity, among oesophageal squamous cell carcinoma (ESCC) cases in low-risk vs. high-risk populations. The objective of this study was to evaluate the association between nut consumption and risk of ESCC in a high-risk population.<h4>Methods</h4>The Golestan Cohort Study enroled 50,045 participants in Northeastern ...[more]

PMID: 29950612

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Project description:ObjectiveIn recent years, the incidence of oesophageal squamous cell carcinoma has been increasing, becoming a major focus of public attention. Despite surgery being the primary treatment method, the long-term prognosis after surgery is also of significant importance. Therefore, this study aims to investigate the impact of dietary behaviour changes on the long-term prognosis of patients with oesophageal squamous cell carcinoma after surgery.MethodsA retrospective cohort study was adopted, involving patients with oesophageal squamous cell carcinoma who underwent surgery at the Department of Thoracic Surgery, Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University from January 1, 2018, to December 31, 2019. Data collected included characteristics of dietary behaviour, complications, postoperative quality of life scores and survival periods. Data were gathered through review of clinical pathological characteristics and patient survey questionnaires.ResultsPatients with oesophageal squamous cell carcinoma who changed their dietary behaviours had a significant reduction in the risk of postoperative complications, higher quality of life scores (mean QoL score NDC: 9.8 vs. DC: 21.1; p < 0.001) and a slightly prolonged overall survival period (univariate hazard ratio: 0.58, 95% CI: 0.40-0.83, p = 0.003). Study findings also indicated age as a significant independent risk factor influencing patient prognosis.ConclusionTo improve postoperative prognosis in patients with oesophageal squamous cell carcinoma, guidance and management of dietary behaviour should be emphasised. Appropriate changes in dietary behaviour are expected to reduce the risk of postoperative complications, improve the quality of life and extend the survival period of patients.Patient or public contributionThe findings of this study have important implications for both patients and the public. By investigating the impact of dietary behaviour changes on the long-term prognosis of patients with oesophageal squamous cell carcinoma after surgery, this study provides valuable insights into potential strategies to improve patient outcomes. For patients, the study emphasises the importance of adopting healthy dietary behaviours after surgery. The results demonstrate that dietary behaviour changes can have a significant impact on the long-term prognosis of postoperative oesophageal squamous cell carcinoma patients. By following a healthy diet, patients may improve their overall quality of life, decrease complications and potentially increase their survival period.

Dataset Information

Nut consumption and the risk of oesophageal squamous cell carcinoma in the Golestan Cohort Study.

Background

Methods

Results

Conclusions

Publications

Nut consumption and the risk of oesophageal squamous cell carcinoma in the Golestan Cohort Study.

Similar Datasets

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