Spatially restricted subcellular Ca²⁺ signaling downstream of store-operated calcium entry encoded by a cortical tunneling mechanism.

ABSTRACT: Agonist-dependent Ca²⁺ mobilization results in Ca²⁺ store depletion and Store-Operated Calcium Entry (SOCE), which is spatially restricted to microdomains defined by cortical ER - plasma membrane contact sites (MCS). However, some Ca²⁺-dependent effectors that localize away from SOCE microdomains, are activated downstream of SOCE by mechanisms that remain obscure. One mechanism proposed initially in acinar cells and termed Ca²⁺ tunneling, mediates the uptake of Ca²⁺ flowing through SOCE into the ER followed by release at distal sites through IP₃ receptors. Here we show that Ca²⁺ tunneling encodes exquisite specificity downstream of SOCE signal by dissecting the sensitivity and dependence of multiple effectors in H

SUBMITTER: Courjaret R 

PROVIDER: S-EPMC6060099 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature