Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man.

ABSTRACT: Individual susceptibility to anxiety disorders after maladaptive responses to stress is not well understood. We now report that while exploring stress responses in mice after traumatic brain injury (TBI), a condition associated to stress susceptibility, we observed that the anxiogenic effects of either TBI or exposure to life-threatening experiences (predator) were blocked when both stressors were combined. Because TBI increases the entrance into the brain of serum insulin-like growth factor I (IGF-I), a known modulator of anxiety with a wide range of concentrations in the human population, we then determined whether circulating IGF-I is related to anxiety measures. In mice, anxiety-like responses to predator were inversely related to circulating IGF-I levels. Other indicators of mood regu

SUBMITTER: Santi A 

PROVIDER: S-EPMC6070549 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature