17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage.

ABSTRACT:

Background and purpose

Hematoma volume is an important determinant of clinical outcome in spontaneous intracerebral hemorrhage (ICH). We performed a genome-wide association study (GWAS) of hematoma volume with the aim of identifying novel biological pathways involved in the pathophysiology of primary brain injury in ICH.

Methods

We conducted a 2-stage (discovery and replication) case-only genome-wide association study in patients with ICH of European ancestry. We utilized the admission head computed tomography to calculate hematoma volume via semiautomated computer-assisted technique. After quality control and imputation, 7 million genetic variants were available for association testing with ICH volume, which was performed separately in lobar and nonlobar ICH cases using lin

SUBMITTER: Marini S 

PROVIDER: S-EPMC6085089 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature