Ovarian environment aging: follicular fluid lipidomic and related metabolic pathways.

ABSTRACT:

Purpose

The decline in female fecundity with age may be caused by decreased oocyte quality, a factor that may be associated with the altered composition of follicular fluid (FF).

Methods

In an effort to better understand follicular aging and the role of lipids in a given biological system, we present a prospective study that compares lipid profiles of FF from women older than 35 years (aging group, n = 12) to women equal or younger than 35 years old (control group, n = 17). FF lipids were extracted, and mass spectra were generated using a Waters Synapt G1 Q-TOF in MS mode. MS data was evaluated for both multi- and univariate statistics. The lipids identified as potential biomarkers of follicle aging were attributed by the online databases Lipid Maps, followed by pathway netw

SUBMITTER: Cordeiro FB 

PROVIDER: S-EPMC6086795 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature