Cerebral metabolic rate of oxygen (CMRO₂ ) mapping by combining quantitative susceptibility mapping (QSM) and quantitative blood oxygenation level-dependent imaging (qBOLD).

ABSTRACT:

Purpose

To map the cerebral metabolic rate of oxygen (CMRO₂ ) by estimating the oxygen extraction fraction (OEF) from gradient echo imaging (GRE) using phase and magnitude of the GRE data.

Theory and methods

3D multi-echo gradient echo imaging and perfusion imaging with arterial spin labeling were performed in 11 healthy subjects. CMRO₂ and OEF maps were reconstructed by joint quantitative susceptibility mapping (QSM) to process GRE phases and quantitative blood oxygen level-dependent (qBOLD) modeling to process GRE magnitudes. Comparisons with QSM and qBOLD alone were performed using ROI analysis, paired t-tests, and Bland-Altman plot.

Results

The average CMRO₂ value in cortical gray matter across subjects were 140.4 ± 14.9, 134.1 ± 1

SUBMITTER: Cho J 

PROVIDER: S-EPMC6097883 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature