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Metabolic acidosis after sodium thiosulfate infusion and the role of hydrogen sulfide.

ABSTRACT: Sodium thiosulfate (STS), first-line treatment for calcific uremic arteriolopathy, causes a mild asymptomatic acidosis in many patients. However, severe, life-threatening acidosis out of proportion with the expected acid load of STS may occur, potentially due to metabolism of STS to hydrogen sulfide.

SUBMITTER: Hunt GM 

PROVIDER: S-EPMC6099024 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Metabolic acidosis after sodium thiosulfate infusion and the role of hydrogen sulfide.

Hunt Guenola M GM   Ryder Hilary F HF  

Clinical case reports 20180701 8

Sodium thiosulfate (STS), first-line treatment for calcific uremic arteriolopathy, causes a mild asymptomatic acidosis in many patients. However, severe, life-threatening acidosis out of proportion with the expected acid load of STS may occur, potentially due to metabolism of STS to hydrogen sulfide. ...[more]

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