A transcriptionally and functionally distinct PD-1⁺ CD8⁺ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.

ABSTRACT: Evidence from mouse chronic viral infection models suggests that CD8⁺ T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade. However, it remains unknown whether T cells in human cancer adopt a similar spectrum of exhausted states based on PD-1 expression levels. We compared transcriptional, metabolic and functional signatures of intratumoral CD8⁺ T lymphocyte populations with high (PD-1^T), intermediate (PD-1^N) and no PD-1 expression (PD-1^-) from non-small-cell lung cancer patients. PD-1^T T cells showed a markedly different transcriptional and metabolic profile from PD-1^N and PD-1^- lymphocytes

SUBMITTER: Thommen DS 

PROVIDER: S-EPMC6110381 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature