Deficiency in Fpr2 results in reduced numbers of Lin^-cKit⁺Sca1⁺ myeloid progenitor cells.

ABSTRACT: The Lin^-c-Kit⁺ Sca-1⁺ cell population in the bone marrow (BM) serves as the direct precursor for differentiation of myeloid cells. In this study, we report that deficiency in Fpr2, a G protein-coupled chemoattractant receptor in mice, is associated with reduced BM nucleated cells, including CD31⁺Ly6C⁺ (granulocytes and monocytes), CD31^-/Ly6C^int (granuloid cells), and CD31^-/Ly6C^high (predominantly monocytes) cells. In particular, the number of Lin^-c-Kit⁺Sca-1⁺ (LKS) cells was reduced in Fpr2^-/- mouse BM. This was supported by observations of the reduced incorporation of intraperitoneally injected bromodeoxyuridine by cells in the c-Kit⁺ po

SUBMITTER: Chen K 

PROVIDER: S-EPMC6120191 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature