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Genome-wide association study for risk taking propensity indicates shared pathways with body mass index.

ABSTRACT: Risk-taking propensity is a trait of significant public health relevance but few specific genetic factors are known. Here we perform a genome-wide association study of self-reported risk-taking propensity among 436,236 white European UK Biobank study participants. We identify genome-wide associations at 26 loci (P?

SUBMITTER: Clifton EAD 

PROVIDER: S-EPMC6123697 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Genome-wide association study for risk taking propensity indicates shared pathways with body mass index.

Clifton Emma A D EAD   Perry John R B JRB   Imamura Fumiaki F   Lotta Luca A LA   Brage Soren S   Forouhi Nita G NG   Griffin Simon J SJ   Wareham Nicholas J NJ   Ong Ken K KK   Day Felix R FR  

Communications biology 20180503

Risk-taking propensity is a trait of significant public health relevance but few specific genetic factors are known. Here we perform a genome-wide association study of self-reported risk-taking propensity among 436,236 white European UK Biobank study participants. We identify genome-wide associations at 26 loci (<i>P</i> < 5 × 10<sup>-8</sup>), 24 of which are novel, implicating genes enriched in the GABA and GABA receptor pathways. Modelling the relationship between risk-taking propensity and b  ...[more]

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