Serum sST2 levels predict severe exacerbation of asthma.

ABSTRACT:

Background

Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 levels in stable asthmatics are a predictor for exacerbation within a short duration.

Methods

This prospective observational study evaluated the serum sST2 levels of 104 asthmatic patients who were treated by a lung disease specialist with follow-ups for 3 months.

Results

High serum sST2 levels (> 18 ng/ml) predicted severe asthma exacerbation within 3 months. Serum sST2 levels correlated positively with asthma severity (treatment step), airway H₂O₂ levels, and serum IL-8 levels. High serum sST2 levels and blood neutrophilia (> 6000 /μl) were

SUBMITTER: Watanabe M 

PROVIDER: S-EPMC6126416 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature