Piqueria trinervia as a source of metabolites against Giardia intestinalis.

ABSTRACT:

Context

Piqueria trinervia Cav. (Asteraceae) is a plant species with a long history in traditional medicine to cure diarrhoea and other digestive disorders.

Objective

The study investigates the antigiardial activity of piquerol, trinervinol, red oil and two fractions (F1 and F2) from P. trinervia.

Materials and methods

P. trinervia was collected in the Ajusco in Mexico City. Aerial parts were ground and mixed with water to obtain the extract, which was treated with dichloromethane to isolate piquerol and trinervinol (P & T). Remnants were the red oil, fractions 1 and 2 (RO, F1 & F2). Trophozoites of Giardia intestinalis were treated with P, T, RO, F1 and F2 at different concentrations (0.78-200 μg/mL) for 48 h. Antigiardial activity was measured using the methylene bl

SUBMITTER: Rufino-Gonzalez Y 

PROVIDER: S-EPMC6130510 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature