The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target.

ABSTRACT: Our hypothesis is that changes in gene and protein expression are crucial to the development of late-onset Alzheimer’s disease. Previously we examined how DNA alleles control downstream expression of RNA transcripts and how those relationships are changed in late-onset Alzheimer’s disease. We have now examined how proteins are incorporated into networks in two separate series and evaluated our outputs in two different cell lines. Our pipeline included the following steps: (i) predicting expression quantitative trait loci; (ii) determining differential expression; (iii) analysing networks of transcript and peptide relationships; and (iv) validating effects in two separate cell lines. We performed all our analysis in two separate brain series to validate effects. Our two series i

SUBMITTER: Petyuk VA 

PROVIDER: S-EPMC6136080 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature