BMP- and neuropilin 1-mediated motor axon navigation relies on spastin alternative translation.

ABSTRACT: Functional analyses of genes responsible for neurodegenerative disorders have unveiled crucial links between neurodegenerative processes and key developmental signalling pathways. Mutations in SPG4-encoding spastin cause hereditary spastic paraplegia (HSP). Spastin is involved in diverse cellular processes that couple microtubule severing to membrane remodelling. Two main spastin isoforms are synthesised from alternative translational start sites (M1 and M87). However, their specific roles in neuronal development and homeostasis remain largely unknown. To selectively unravel their neuronal function, we blocked spastin synthesis from each initiation codon during zebrafish development and performed rescue analyses. The knockdown of each isoform led to different motor neuron and locomo

SUBMITTER: Jardin N 

PROVIDER: S-EPMC6141775 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature