Ontology highlight
ABSTRACT:
SUBMITTER: Chen D
PROVIDER: S-EPMC6146919 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Chen Dapeng D Gomes Fabio F Abeykoon Dulith D Lemma Betsegaw B Wang Yan Y Fushman David D Fenselau Catherine C
Analytical chemistry 20180307 6
Post-translational modifications by the covalent attachment of Rub1 (NEDD8), ubiquitin, SUMO, and other small signaling proteins have profound impacts on the functions and fates of cellular proteins. Investigations of the relationship of these bioactive structures and their functions are limited by analytical methods that are scarce and tedious. A novel strategy is reported here for the analysis of branched proteins by top-down mass spectrometry and illustrated by application to four recombinant ...[more]