Impact of oversedation prevention in ventilated critically ill patients: a randomized trial-the AWARE study.

ABSTRACT:

Background

Although oversedation has been associated with increased morbidity in ventilated critically ill patients, it is unclear whether prevention of oversedation improves mortality. We aimed to assess 90-day mortality in patients receiving a bundle of interventions to prevent oversedation as compared to usual care.

Methods

In this randomized multicentre trial, all adult patients requiring mechanical ventilation for more than 48 h were included. Two groups were compared: patients managed according to usual sedation practices (control), and patients receiving sedation according to an algorithm which provided a gradual multilevel response to pain, agitation, and ventilator dyssynchrony with no specific target to alter consciousness and no use of sedation scale and promoted

SUBMITTER: SRLF Trial Group 

PROVIDER: S-EPMC6150862 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature