Low-dose aspirin and preterm birth: a randomized controlled trial.

ABSTRACT:

Objective

To evaluate the association between low-dose aspirin initiated before conception and the risk of preterm birth.

Methods

This was a secondary analysis of the Effects of Aspirin in Gestation and Reproduction trial. Women with a history of pregnancy loss (original stratum: one loss less than 20 weeks of gestation during the previous year; expanded stratum: one or two losses with no restrictions on timing or gestational age of the losses) were randomized to either daily low-dose aspirin (81 mg, n=615) and folic acid or folic acid alone (placebo; n=613). Preterm birth was compared between groups using intent-to-treat analysis.

Results

Preterm birth rates were 4.1% (22/535 low-dose aspirin) and 5.7% (31/543 placebo) (relative risk [RR] 0.72, 95% confidence interva

SUBMITTER: Silver RM 

PROVIDER: S-EPMC6152923 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature