Changes in Plasma Acylcarnitine and Lysophosphatidylcholine Levels Following a High-Fructose Diet: A Targeted Metabolomics Study in Healthy Women.

ABSTRACT:

Background

The consumption of high amounts of fructose is associated with metabolic diseases. However, the underlying mechanisms are largely unknown.

Objective

To determine the effects of high fructose intake on plasma metabolomics.

Study design

We enrolled 12 healthy volunteers (six lean and six obese women, age 24⁻35 years) in a crossover intervention study. All participants carried out three diets: (1) low fructose (<10 g/day); (2) high fructose (100 g/day) from natural food sources (fruit); and (3) high fructose (100 g/day) from high fructose syrup (HFS).

Outcome measures

The primary outcome was changes in plasma metabolites measured by targeted metabolomics.

Results

High compared to low fructose diets caused a marked metabolite class separation, esp

SUBMITTER: Gonzalez-Granda A 

PROVIDER: S-EPMC6165514 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature