Modulation of three key innate immune pathways for the most common retinal degenerative diseases.
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ABSTRACT:
SUBMITTER: Akhtar-Schafer I
PROVIDER: S-EPMC6180304 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Modulation of three key innate immune pathways for the most common retinal degenerative diseases.
Akhtar-Schäfer Isha I Wang Luping L Krohne Tim U TU Xu Heping H Langmann Thomas T
EMBO molecular medicine 20181001 10
This review highlights the role of three key immune pathways in the pathophysiology of major retinal degenerative diseases including diabetic retinopathy, age-related macular degeneration, and rare retinal dystrophies. We first discuss the mechanisms how loss of retinal homeostasis evokes an unbalanced retinal immune reaction involving responses of local microglia and recruited macrophages, activity of the alternative complement system, and inflammasome assembly in the retinal pigment epithelium ...[more]
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