Development of novel aptamers for low-density lipoprotein particle quantification.
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ABSTRACT:
SUBMITTER: Klapak D
PROVIDER: S-EPMC6181373 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Development of novel aptamers for low-density lipoprotein particle quantification.
Klapak Daniel D Broadfoot Sarah S Penner Gregory G Singh Anup A Inapuri Eshwar E
PloS one 20181011 10
Cardiovascular disease (CVD) remains the leading cause of death worldwide. Low-density lipoprotein cholesterol (LDL-C) is commonly used for CVD risk assessment; however, recent research has shown LDL particle (LDL-P) number to be a more sensitive indicator of CVD risk than both LDL-C and non-high-density lipoprotein cholesterol (HDL-C). Described herein are five single stranded DNA aptamers with dissociation constants in the low picomolar range specific to LDL-P and its subfractions. Furthermore ...[more]
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2020-11-02 | MSV000086397 | MassIVE