Calcium-induced chloride secretion is decreased by Resveratrol in ileal porcine tissue.

ABSTRACT:

Objective

Chloride (Cl^-) secretion is crucial for intestinal fluid secretion. Therefore, effects of the polyphenol Resveratrol (RSV) on Cl^- secretion have been investigated. In a previous study, we observed effects of RSV on forskolin-induced Cl^- secretion in the porcine jejunum but not the ileum although RSV itself induced a transepithelial ion current that may represent Cl^- secretion in the ileum. The aim of this study was to gain further insights regarding the effects of RSV on characteristics of Cl^- secretion in the porcine ileum using the Ussing chamber technique (recording of short circuit currents (I_sc) as a measure for epithelial net ion transfer).

Results

RSV increased the I_sc in the porcin

SUBMITTER: Hoppe S 

PROVIDER: S-EPMC6182809 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature