Long-term Glycemic Control and Dementia Risk in Type 1 Diabetes.

ABSTRACT:

Objective

Individuals with type 1 diabetes have experienced an increase in life expectancy, yet it is unknown what level of glycemic control is ideal for maintaining late-life brain health. We investigated the association of long-term glycemic control with dementia in older individuals with type 1 diabetes.

Research design and methods

We followed 3,433 members of a health care system with type 1 diabetes, aged ≥50 years, from 1996 to 2015. Repeated measurements of hemoglobin A_1c (HbA_1c), dementia diagnoses, and comorbidities were ascertained from health records. Cox proportional hazards models were fit to evaluate the association of time-varying glycemic exposure with dementia, with adjustment for age, sex, race/ethnicity, baseline health conditions, an

SUBMITTER: Lacy ME 

PROVIDER: S-EPMC6196833 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature