Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study.

ABSTRACT:

Background

The interaction of the gut microbiota with the human host is implicated in the pathogenesis of inflammatory and immunological diseases including ulcerative colitis (UC). Faecal microbiota transplantation (FMT) as a method of restoring gut microbial diversity is of increasing interest as a therapeutic approach in the management of UC. The current literature lacks consensus about the dose of FMT, route of administration and duration of response.

Methods and analysis

This single-blinded randomised trial will explore the feasibility of FMT in 30 treatment-naïve patients with histologically confirmed distal UC limited to the recto-sigmoid region (up to 40 cm from the anal verge). This study aims to estimate the magnitude of treatment response to FMT under controlled co

SUBMITTER: Jitsumura M 

PROVIDER: S-EPMC6196852 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature