DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.

ABSTRACT: Many hemostatic factors are associated with age and age-related diseases; however, much remains unknown about the biological mechanisms linking aging and hemostatic factors. DNA methylation is a novel means by which to assess epigenetic aging, which is a measure of age and the aging processes as determined by altered epigenetic states. We used a meta-analysis approach to examine the association between measures of epigenetic aging and hemostatic factors, as well as a clotting time measure. For fibrinogen, we performed European and African ancestry-specific meta-analyses which were then combined via a random effects meta-analysis. For all other measures we could not estimate ancestry-specific effects and used a single fixed effects meta-analysis. We found that 1-year higher extrinsic epigen

SUBMITTER: Ward-Caviness CK 

PROVIDER: S-EPMC6202911 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature