Down-regulation of CXCL11 inhibits colorectal cancer cell growth and epithelial-mesenchymal transition.

ABSTRACT:

Background

The poor prognosis of colorectal cancer (CRC) largely results from local invasion and tumor metastases. Epithelial-mesenchymal transition (EMT) is a key step in the progression of solid tumors and plays a vital role in tumor metastasis. Recent studies demonstrate that C-X-C motif chemokine 11 (CXCL11) is involved in various cancers' progression. However, its biological activity in CRC needs deeper exploration.

Methods

The level of CXCL11 in CRC tissues and cell lines was determined using the quantitative real-time PCR (qRT-PCR) assay. The MTT, colony formation, wound healing and Transwell invasion assays were applied to assess the role of CXCL11 in CRC cell growth, migration and invasion, in vitro, respectively. A xenograft model was constructed to analyze the fun

SUBMITTER: Gao YJ 

PROVIDER: S-EPMC6205823 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature