Ontology highlight
ABSTRACT:
SUBMITTER: Mesa KR
PROVIDER: S-EPMC6214709 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cell stem cell 20180927 5
Maintenance of adult tissues depends on sustained activity of resident stem cell populations, but the mechanisms that regulate stem cell self-renewal during homeostasis remain largely unknown. Using an imaging and tracking approach that captures all epidermal stem cell activity in large regions of living mice, we show that self-renewal is locally coordinated with epidermal differentiation, with a lag time of 1 to 2 days. In both homeostasis and upon experimental perturbation, we find that differ ...[more]